12 december 2010 - Op de Spike TV Video Game Awards is Red Dead Redemption verkozen tot de beste game van 2010. Het spel liet daarmee alle concurrentie van dit jaar achter zit, al zijn ook diverse andere toppers in de prijzen gevallen. Zo is Mass Effect 2 de beste RPG van dit jaar, en is Call of Duty: Black Ops logischerwijs de beste shooter van dit jaar. Halo: Reach mocht de prijs voor beste multiplayer game in ontvangst nemen.

Studio of the Year: BioWare
Best Wii Game: Super Mario Galaxy 2
Best Xbox 360 Game: Mass Effect 2
Best PS3 Game: God of War III
Best PC Game: StarCraft II: Wings of Liberty
Best Handheld Game: God of War: Ghost of Sparta
Best Shooter: Call of Duty: Black Ops
Best Action-Adventure Game: Assassin’s Creed: Brotherhood
Best RPG: Mass Effect 2
Best Multiplayer Game: Halo: Reach
Best Individual Sports Game: Tiger Woods PGA Tour 11
Best Team Sports Game: NBA 2K11
Best Driving Game: Need For Speed: Hot Pursuit
Best Music Game: Rock Band 3
Best Soundtrack: DJ Hero 2
Best Song in a Game: Far Away door José González
Best Original Score: Red Dead Redemption
Best Graphics: God of War III
Best Adapted Video Game: Scott Pilgrim vs. The World: The Game
Best Performance by a Human Male: Neil Patrick Harris als Peter Parker/Amazing Spider-Man
Best Performance by a Human Female: Tricia Helfer als Sarah Kerrigan
Best Downloadable Game: Costume Quest
Best DLC: Red Dead Redemption – Undead Nightmare
Best Independent Game: Limbo
Most Anticipated Game: Portal 2
Game of the Year: Red Dead Redemption